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Effect of parenteral fluoroquinolone administration on persistence of vancomycin-resistant Enterococcus faecium in

Curtis J Donskey1, Marion S Helfand, Nicole J Pultz

  • 1Research Service. Medical Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. curtis123@yahoo.com

Antimicrobial Agents and Chemotherapy
|December 25, 2003
PubMed

Insights

Certain fluoroquinolone antibiotics, like moxifloxacin and gatifloxacin, can promote vancomycin-resistant Enterococcus faecium (VRE) overgrowth in mice. However, levofloxacin and ciprofloxacin did not show this effect, indicating varied impacts of fluoroquinolones on VRE colonization.

Area of Science:

  • Microbiology
  • Pharmacology
  • Infectious Diseases

Background:

  • Vancomycin-resistant Enterococcus faecium (VRE) is a significant cause of healthcare-associated infections.
  • Antibiotic use is a major risk factor for VRE colonization and subsequent infection.
  • Fluoroquinolones are broad-spectrum antibiotics with varying effects on gut microbiota.

Purpose of the Study:

  • To investigate the impact of subcutaneous fluoroquinolone administration on VRE stool colonization in a murine model.
  • To determine if specific fluoroquinolones differentially affect VRE persistence and density.

Main Methods:

  • Mice were colonized with VRE.
  • Subcutaneous injections of levofloxacin, ciprofloxacin, moxifloxacin, gatifloxacin, or saline were administered in a dose-dependent manner.
  • Stool samples were collected to quantify VRE density and assess persistence over time.

Main Results:

  • Moxifloxacin and gatifloxacin significantly promoted persistent VRE overgrowth in a dose-dependent manner.
  • Levofloxacin and ciprofloxacin did not promote VRE colonization compared to saline controls.
  • These findings suggest differential effects of fluoroquinolones on VRE gut colonization.

Conclusions:

  • Subcutaneous administration of moxifloxacin and gatifloxacin can lead to persistent VRE overgrowth in mice.
  • Levofloxacin and ciprofloxacin do not appear to promote VRE colonization.
  • These results highlight the importance of considering specific antibiotic agents when assessing the risk of VRE colonization.

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