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Updated: Aug 17, 2026

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
Published on: January 7, 2014
Flexible matching in case-control studies of gene-environment interactions
Catherine L Saunders1, Jennifer H Barrett
1Genetic Epidemiology Division, Cancer Research UK Clinical Centre at Leeds, Leeds, United Kingdom.
Abstract:
Because of the lack of power of case-control study designs to detect gene-environment interactions, flexible matching has recently been proposed as a method of improving efficiency. In this paper, the authors consider a large-sample approximation method that allows estimation of the most efficient matching strategy when genotype and exposure are either independent or associated. The authors provide tables of the sample sizes required to detect gene-environment interactions if this flexible matching strategy is followed, and they make brief comparisons with other study designs.
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