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The genomic threading database.

Liam J McGuffin1, Stefano Street, Søren-Aksel Sørensen

  • 1Department of Computer Science, University College London, Gower Street, London WC1E 6BT, UK. l.mcguffin@cs.ucl.ac.uk

Bioinformatics (Oxford, England)
|December 25, 2003
PubMed
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The Genomic Threading Database provides structural genome annotations for over 100 organisms using GenTHREADER software and grid technology. This resource aids in understanding genomic structures across diverse species.

Area of Science:

  • Bioinformatics
  • Genomics
  • Structural Biology

Background:

  • The Genomic Threading Database (GTD) is a crucial resource for genomic information.
  • It currently houses structural annotations for a vast number of sequenced genomes.
  • Access to the GTD is available at http://bioinf.cs.ucl.ac.uk/GTD.

Purpose of the Study:

  • To present the current state and content of the Genomic Threading Database.
  • To highlight the database's utility in providing structural genomic annotations.
  • To showcase the integration of advanced computational methods for genomic analysis.

Main Methods:

  • Utilizing a modified version of the GenTHREADER software for annotation.
  • Implementing grid technology to enhance computational efficiency and scalability.

Related Experiment Videos

  • Curating and integrating structural annotations for newly sequenced genomes.

    • Main Results:

    • The database contains structural annotations for over 100 recently sequenced organisms.
    • The annotation process leverages a refined GenTHREADER algorithm.
    • Grid technology facilitates the processing of large-scale genomic data.

    Conclusions:

    • The Genomic Threading Database is a valuable and expanding resource for genomic structural information.
    • The applied methods ensure efficient and comprehensive annotation of diverse genomes.
    • This database supports further research in comparative genomics and structural biology.