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Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability
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Intracranial arterial dolichoectasia and its relation with atherosclerosis and stroke subtype

Fernando Pico1, Julien Labreuche, Pierre-Jean Touboul

  • 1Department of Neurology, Versailles Hospital, France.

Neurology
|December 25, 2003
PubMed

Insights

Intracranial arterial dolichoectasia (IADE) is linked to vascular risks like hypertension and male sex, and more frequent lacunar infarcts. IADE showed no association with carotid atherosclerosis.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Radiology

Background:

  • Intracranial arterial dolichoectasia (IADE) is a condition characterized by abnormal widening and elongation of intracranial arteries.
  • Understanding the associations of IADE with vascular risk factors and stroke subtypes is crucial for patient management.

Purpose of the Study:

  • To investigate the relationship between intracranial arterial dolichoectasia (IADE) and vascular risk factors.
  • To examine the association between IADE and carotid artery atherosclerosis.
  • To determine the relationship between IADE and stroke subtypes.

Main Methods:

  • MRI scans of 510 patients with confirmed brain infarction were analyzed.
  • Intracranial arterial dolichoectasia (IADE) was diagnosed by consensus between two neurologists.
  • Diameter measurements of seven main intracranial arteries were performed to characterize IADE.

Main Results:

  • 12% of patients had IADE. Associations were found with older age, male sex, hypertension, and prior myocardial infarction.
  • No significant association was observed between IADE and carotid atherosclerosis markers (plaque or intima-media thickening).
  • Lacunar infarcts were more frequent in patients with IADE compared to atherothrombotic infarcts.

Conclusions:

  • IADE is associated with several vascular risk factors including age, male sex, hypertension, and a history of myocardial infarction.
  • Carotid atherosclerosis was not found to be associated with IADE.
  • Lacunar infarcts are more common in patients with IADE, suggesting a potential link to specific stroke mechanisms.
Abstract

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