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Propriospinal myoclonus in multiple sclerosis.

R Kapoor1, P Brown, P D Thompson

  • 1University Department of Clinical Neurology, National Hospital for Neurology and Neurosurgery, London, UK.

Journal of Neurology, Neurosurgery, and Psychiatry
|November 1, 1992
PubMed
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Multiple sclerosis can cause segmental myoclonus, a condition previously unlinked to the disease. This study details a case where cervical cord lesions generated slow, variable muscle activity characteristic of propriospinal myoclonus.

Area of Science:

  • Neurology
  • Neurophysiology
  • Clinical Neuroscience

Background:

  • Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
  • Segmental myoclonus involves involuntary muscle jerks within a specific body segment.
  • Propriospinal myoclonus is a rare movement disorder characterized by slow, rhythmic myoclonic jerks.
  • The association between MS and propriospinal myoclonus has not been previously reported.

Observation:

  • A patient with multiple sclerosis presented with clinical and electrophysiological features of segmental myoclonus.
  • The myoclonus affected the right arm and upper trunk.
  • Magnetic Resonance Imaging (MRI) revealed lesions in the cervical cord.

Findings:

  • Electrophysiological studies indicated that the myoclonus originated from a generator site in the cervical cord.

Related Experiment Videos

  • The spread of electromyographic (EMG) activity during each myoclonic jerk was observed to be slow and variable.
  • These electrophysiological findings are characteristic of propriospinal myoclonus.

    • Implications:

    • This case suggests a potential link between multiple sclerosis and propriospinal myoclonus.
    • The findings expand the spectrum of neurological manifestations associated with MS.
    • Further research is warranted to understand the pathophysiology and prevalence of this association.