Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Striatal dysfunction in Rolling mouse Nagoya: an electrophysiological study.

H Tomoda1, M Kato, S Sakata

  • 1Department of Clinical Neurophysiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

Journal of the Neurological Sciences
|October 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The conditioning effect of rk-28 in a combined treatment with irradiation against v-79 cells.

Oncology reports·2011
Same author

Inguinal lymph node recurrence of mucosal cancer of the stomach.

Oncology reports·2011
Same author

A case of liver metastasis of malignant peritoneal mesothelioma successfully treated by surgery.

Oncology reports·2011
Same author

A flow cytometric analysis of the nuclear DNA content between primary and recurrent colorectal cancers.

Oncology reports·2011
Same author

Changing site distribution of Japanese colorectal cancer.

Oncology reports·2011
Same author

Nm23 expression in human gastric cancers - possible correlation of nm23 with lymph-node metastasis.

International journal of oncology·2011

The Rolling mouse Nagoya exhibits increased globus pallidus (GP) neuronal activity and altered responses to striatal stimulation, indicating a neurophysiological basis for its motor deficits. This study reveals key differences in GP neuron function in this neurological mutant.

Area of Science:

  • Neuroscience
  • Neurobiology
  • Genetics

Background:

  • The Rolling mouse Nagoya (rol/rol) is an experimental model for neurological disorders.
  • Understanding the neuronal mechanisms underlying its motor disturbances is crucial for research.

Purpose of the Study:

  • To investigate the physiological characteristics of globus pallidus (GP) neurons in the Rolling mouse Nagoya.
  • To compare GP neuronal activity and responses in mutant mice with normal controls and heterozygotes.

Main Methods:

  • Electrophysiological recordings of GP neurons in anesthetized mice (rolling, heterozygotes, and controls).
  • Analysis of spontaneous unit discharges and responses to striatal electrical stimulation.
  • Measurement of field potentials in the GP evoked by striatal stimulation.

Related Experiment Videos

Main Results:

  • Rolling mice showed significantly higher spontaneous unit activity in the GP compared to controls and heterozygotes.
  • A significantly lower percentage of GP neurons in rolling mice exhibited inhibitory responses to striatal stimulation.
  • Evoked positive field potentials in the GP were significantly smaller in amplitude in rolling mice.

Conclusions:

  • The findings suggest altered GP neuronal function in the Rolling mouse Nagoya, contributing to motor disturbances.
  • Results align with previous observations of altered metabolism and GABA levels in the GP and substantia nigra pars reticulata (SNr) of rolling mice.