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Updated: Aug 29, 2026

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
Published on: August 9, 2012
Cell biology of bladder development and the role of the extracellular matrix
L S L McCarthy1, N Smeulders, D T Wilcox
1Nephro-Urology Unit, Institute of Child Health, University College London, London, UK. McCarL@gosh.nhs.uk
Abstract:
The bladder is unique. It is the most distensible organ in the body. If the normal pattern of development is disturbed, the bladder can become dysfunctional and poorly compliant. Renal outcome is intimately linked to bladder function and hence bladder development. In this review we describe our current knowledge of the molecular processes that govern bladder development, with particular emphasis on the role of the extracellular matrix. Finally, we suggest a hypothetical model for bladder development.
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