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Published on: November 15, 2019
Expression of SR-BI receptor and StAR protein in rat ocular tissues
Alexandra C Provost1, Marie O Péquignot, Karine M Sainton
1Centre de recherche thérapeutique en ophtalmologie (CERTO), équipe d'accueil no 2502 du ministère de l'Enseignement supérieur, université René-Descartes, faculté de médecine Necker-Enfants Malades, 156, rue de Vaugirard 75015 Paris, France.
Abstract:
The class-B type-I scavenger receptor (SR-BI) plays a key role in cholesterol homeostasis; it mediates the selective uptake of lipoprotein cholesterol to steroidogenic tissues. We show by RT-PCR, western blot, in situ hybridization and immunohistochemistry analysis that SR-BI is highly expressed in different neuro-retinal and non-neuronal cells types on rat eye. Immunohistochemistry of the steroidogenic acute regulatory protein (StAR) involved in neurosteroid production showed the same expression pattern than SR-BI in rat eye. Our results may suggest a key role of these genes in the ocular cholesterol metabolism for membranes biosynthesis and neurosteroidogenesis.
