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L-CAM expression in normal, premalignant, and malignant colon mucosa
A A van der Wurff1, J ten Kate, E P van der Linden
1Department of Pathology, University of Limburg, Maastricht, The Netherlands.
The Journal of Pathology
|November 1, 1992
Summary
Loss of L-CAM cell adhesion molecule expression in colon tissue may occur early in neoplasia development. However, L-CAM levels do not predict invasive or metastatic potential in colon cancer.
Area of Science:
- Oncology
- Cell Biology
- Gastroenterology
Background:
- L-CAM (L-CAM) is a cell adhesion molecule found on epithelial cells.
- L-CAM acts as an invasion suppressor in carcinoma cell lines.
Purpose of the Study:
- To investigate L-CAM expression in colon neoplasms.
- To determine if L-CAM expression differentiates invasive from non-invasive or metastatic from non-metastatic colon tumors.
Main Methods:
- Immunohistochemistry using the 6F9 monoclonal anti-L-CAM antibody.
- Analysis of L-CAM expression in normal colon mucosa, adenomas, and carcinomas.
Main Results:
- Normal colon mucosa shows distinct L-CAM immunoreactivity.
- L-CAM expression was weaker in adenomas and carcinomas, decreasing with differentiation.
- No correlation was found between L-CAM expression and Dukes stage or tumor area.
- L-CAM expression patterns varied in carcinomas, with some showing loss or luminal surface expression.
Conclusions:
- L-CAM expression dysregulation or loss is an early event in colon neoplasia.
- L-CAM expression does not correlate with the invasive or metastatic potential of colon tumors.