Related Experiment Video

Updated: Aug 29, 2026

Live-imaging of Breast Epithelial Cell Migration After the Transient Depletion of TIP60
08:13

Live-imaging of Breast Epithelial Cell Migration After the Transient Depletion of TIP60

Published on: December 7, 2017

TIP30 deficiency increases susceptibility to tumorigenesis

Mitsuhiro Ito1, Chao Jiang, Kristy Krumm

  • 1Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York, USA.

Cancer Research
|December 26, 2003
PubMed

Insights

The tumor suppressor TIP30 (also known as CC3 or Htatip2) is crucial for preventing cancer. Loss of TIP30 function leads to increased tumor development, particularly hepatocellular carcinoma, highlighting its role in tumor suppression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • TIP30 (CC3/Htatip2) is a potential metastasis suppressor, promoting apoptosis and inhibiting angiogenesis.
  • In vitro studies suggest TIP30 acts as a tumor suppressor, but in vivo evidence and human cancer associations were lacking.

Purpose of the Study:

  • To investigate the in vivo role of TIP30 in tumor development.
  • To determine if TIP30 deficiency contributes to cancer susceptibility.
  • To assess TIP30 expression and mutation status in human hepatocellular carcinoma.

Main Methods:

  • Utilized genetically engineered mice and TIP30-deficient cells.
  • Performed in vivo tumor incidence studies.
  • Conducted immunohistochemical analysis and gene sequencing on human hepatocellular carcinoma samples.

Main Results:

  • TIP30-deficient mice exhibited a high incidence of hepatocellular carcinoma and other tumors.
  • Loss of TIP30 increased fibroblast susceptibility to SV40 large T antigen-induced transformation.
  • Reduced TIP30 expression was observed in 33% of human hepatocellular carcinomas, with some harboring mutations.

Conclusions:

  • The Tip30 gene functions as a tumor susceptibility gene.
  • TIP30 plays a significant role in suppressing hepatocarcinogenesis.
  • Loss or mutation of TIP30 contributes to human liver cancer development.

More Related Videos

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)04:12

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)

Published on: December 19, 2019

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer08:34

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Published on: April 13, 2015

Related Concept Videos

Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...