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Reduced short-term obsessive-compulsive symptoms in schizophrenic patients treated with risperidone: a single-blind
Baybars Veznedaroglu1, Eyup Sabri Ercan, Bulent Kayahan
1Department of Psychiatry, School of Medicine, Ege University, Bornova, Izmir, Turkey. veznedaroglu@superonline.com
Background:
Risperidone is a widely used agent as first-line treatment in schizophrenia with a favorable side-effect profile. However, a number of case reports have suggested an increase in obsessive-compulsive symptoms in patients treated with risperidone.
Objective:
The aim of this study was to investigate the effect of risperidone on obsessive-compulsive symptoms in the treatment of schizophrenia.
Method:
Forty patients with DSM-IV diagnosis of schizophrenia were included in the study. The Yale-Brown obsessive compulsive scale was administered before, at the end of first and second months of treatment. Paired-samples t-test was used to compare the three assessments.
Results:
There was not an increase, but a significant decrease, in YBOCS scores over time during risperidone treatment (p<0.05).
Conclusion:
In the present study risperidone caused a significant decrease in obsessive-compulsive symptoms in the treatment of schizophrenia.
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