Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inflammatory bowel disease emergencies.

Onki Cheung1, Miguel D Regueiro

  • 1Inflammatory Bowel Disease Center, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Scaife Hall, Room 566, 3550 Terrace Street, Pittsburgh, PA 15261, USA.

Gastroenterology Clinics of North America
|December 31, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An International Consensus on Appropriate Management of Corticosteroids in Clinical Trials in Inflammatory Bowel Disease.

Gastroenterology·2025
Same author

Safety Outcomes in Patients With Ulcerative Colitis Using a Healthcare Administrative Database in the United States.

Inflammatory bowel diseases·2025
Same author

Preoperative Use of Multiple Advanced Therapies Is Not Associated With Endoscopic Inflammatory Pouch Diseases.

Inflammatory bowel diseases·2023
Same author

Crohn's disease shared decision making intervention leads to more patients choosing combination therapy: a cluster randomised controlled trial.

Alimentary pharmacology & therapeutics·2022
Same author

Risk Prediction and Comparative Efficacy of Anti-TNF vs Thiopurines, for Preventing Postoperative Recurrence in Crohn's Disease: A Pooled Analysis of 6 Trials.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2021
Same author

Older Adult Patients Use More Aminosalicylate Monotherapy Compared With Younger Patients With Inflammatory Bowel Disease: TARGET-IBD.

Journal of clinical gastroenterology·2021
Same journal

Living Donor Intestinal and Liver Transplantation.

Gastroenterology clinics of North America·2026
Same journal

Living Abdominal Organ Donation: A Plan B That Saves Lives.

Gastroenterology clinics of North America·2026
Same journal

Long-Term Outcomes of Living Liver Donors.

Gastroenterology clinics of North America·2026
Same journal

Perioperative Management of Living Liver Donor Patients.

Gastroenterology clinics of North America·2026
Same journal

Living Donor Liver Transplantation for Colorectal Cancer Liver Metastasis.

Gastroenterology clinics of North America·2026
Same journal

Living Donor Liver Graft in Adult Populations: Donor Selection and Workup.

Gastroenterology clinics of North America·2026
See all related articles

Emergency complications of inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), are rare but serious. Advances in IBD treatment aim to prevent these potentially life-threatening conditions.

Area of Science:

  • Gastroenterology and Internal Medicine
  • Surgical Gastroenterology

Background:

  • Inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD), can lead to severe emergency complications.
  • These complications, though infrequent, pose significant risks including mortality, surgical intervention, and irreversible organ damage.

Purpose of the Study:

  • To outline the spectrum of emergency complications associated with UC and CD.
  • To discuss the common extraintestinal manifestations presenting as emergencies in IBD patients.
  • To highlight recent advancements in IBD pathogenesis and their potential impact on complication prevention.

Main Methods:

  • Review of common emergency complications in UC (fulminant colitis, toxic megacolon, bleeding) and CD (abscesses, intestinal obstruction).

Related Experiment Videos

  • Identification of emergency extraintestinal manifestations (thromboembolic events, ocular, hepatobiliary diseases).
  • Discussion of treatment outcomes, including medical management and surgical interventions like proctocolectomy and intestinal resection.

    • Main Results:

    • UC complications frequently necessitate proctocolectomy despite medical therapy.
    • CD complications typically require surgical intervention and intestinal resection.
    • Certain extraintestinal manifestations like thromboemboli, uveitis, and primary sclerosing cholangitis (PSC) may not respond to standard IBD treatment.

    Conclusions:

    • Emergency complications of IBD, while rare, are critical and can lead to significant morbidity and mortality.
    • Recent discoveries in IBD pathogenesis offer hope for improved early treatment strategies.
    • Future treatments targeting IBD's underlying mechanisms may prevent severe complications and alter the disease's natural course.