Related Experiment Video
Updated: Aug 29, 2026
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Effects of local administration of growth hormone in peri-implant bone: an experimental study with implants in rabbit
Isabel F Tresguerres1, Luis Blanco, Celia Clemente
1Department of Oral Medicine and Buccofacial Surgery, School of Dentistry, Complutense University, Madrid, Spain. f3f@eresmas.com
Purpose:
The objective of this study was to evaluate the qualitative and quantitative differences that could appear in newly formed peri-implant bone around Screw-Vent implants placed in rabbit tibiae when treated with local administration of growth hormone (GH).
Materials And Methods:
Eight New Zealand rabbits were randomly divided into 2 groups: the experimental group, which received 4 IU of GH in the form of lyophilized powder added to the ostectomy site before implant placement, and the control group, which did not receive GH before implant placement. Animals were sacrificed 2 weeks later, and histologic sections were obtained for histomorphometry and observation under light microscopy.
Results:
The sections in the GH-treated group presented enhanced growth of new trabeculae from the periosteal tissue, and the bone-to-implant contact in the experimental group was significantly greater (P < .05).
Discussion:
Local administration of GH stimulated a more dramatic effect than that seen previously with systemic GH administration, prompting growth from both the periosteum and endosteum.
Conclusions:
Local administration of GH at the time of implant placement could enhance peri-implant bone reaction.
