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Periodic lateralized epileptiform discharges in children

Hideto Yoshikawa1, Tokinari Abe

  • 1Department of Pediatrics, Niigata City General Hospital, Niigata, Japan. hideto@mocha.ocn.ne.jp

Journal of Child Neurology
|December 31, 2003
PubMed

Insights

Periodic lateralized epileptiform discharges (PLEDs) in children can indicate serious cerebral conditions like influenza-associated encephalopathy. This study highlights PLEDs as a significant indicator in acute pediatric neurological disorders, despite not being disease-specific.

Area of Science:

  • Pediatric Neurology
  • Neurophysiology
  • Infectious Diseases

Background:

  • Periodic lateralized epileptiform discharges (PLEDs) are recognized EEG patterns.
  • Their specific etiological significance in acute pediatric cerebral involvement requires further elucidation.
  • This study investigates the spectrum of conditions associated with PLEDs in children.

Observation:

  • Thirteen pediatric patients with PLEDs during acute cerebral involvement were analyzed.
  • Diagnoses included influenza-associated encephalopathy, limbic encephalitis, theophylline-associated seizures, Mycoplasma pneumoniae encephalitis, acute encephalopathy, and bacterial meningitis.
  • All patients experienced seizures, with six exhibiting hemiconvulsions.

Findings:

  • PLEDs were observed in diverse acute pediatric neurological conditions.
  • Influenza-associated encephalopathy was a notable cause among the studied cohort.
  • Seizures and hemiconvulsions were common clinical manifestations in patients with PLEDs.

Implications:

  • PLEDs serve as a critical neurophysiological marker in acute pediatric neurological emergencies.
  • Recognizing PLEDs can aid in the early identification of severe underlying cerebral pathologies.
  • Further research is warranted to explore the prognostic value and specific diagnostic contributions of PLEDs in pediatric neurology.

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