Related Experiment Video
Updated: Jul 29, 2026
10:28
A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
[Hepatitis E virus: current status]
María Teresa Pérez-Gracia1, Manuel Rodríguez-Iglesias
1Departamento de Atención Sanitaria, Salud Pública y Sanidad Animal. Universidad Cardenal Herrera-CEU. Moncada. Valencia. España. teresa@uch.ceu.es
Medicina Clinica
|December 31, 2003
Summary
Hepatitis E virus (HEV) is a significant cause of enterically transmitted hepatitis, increasingly recognized as a zoonotic disease. New HEV strains in animals suggest a growing risk in non-endemic regions.
Area of Science:
- Virology
- Hepatology
- Public Health
Context:
- Hepatitis E is a major cause of enterically transmitted hepatitis in tropical/subtropical regions with poor sanitation.
- The Hepatitis E virus (HEV) is an RNA virus responsible for water-borne outbreaks and sporadic cases.
- Recent HEV strains found in swine and humans in industrialized countries raise new concerns.
Purpose:
- To review the current knowledge on HEV biology, structure, and transmission.
- To analyze HEV diagnosis and infection in low-incidence areas.
- To explore the role of animals as potential vectors for HEV.
Summary:
- HEV is a non-enveloped, positive-sense RNA virus.
- Novel HEV strains closely related to swine isolates suggest zoonotic transmission.
- Hepatitis E is emerging as a concern in non-endemic countries.
Impact:
- Highlights the zoonotic potential of Hepatitis E virus.
- Underscores the need for vigilance in non-endemic regions.
- Informs public health strategies for managing emerging infectious diseases.
Related Concept Videos
01:18Yellow Fever
Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...
01:25Hepatitis
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
01:28Viral Hepatitis I: Introduction
Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
01:29Hepatic Encephalopathy
DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...