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Isolation of alpha-glusosidase inhibitors from hyssop (Hyssopus officinalis)
Hideyuki Matsuura1, Hiroyuki Miyazaki, Chikako Asakawa
1Northern Advancement Center for Science and Technology, Kita-21, Nishi-12, Sapporo, Hokkaido, 001-0021, Japan. matsuura@chem.agr.hokudai.ac.jp
Abstract:
alpha-Glucosidase inhibitory activity was found in aqueous methanol extracts of dried hyssop (Hyssopus officinalis) leaves. Active principles against alpha-glucosidase, prepared from rat small intestine acetone powders, were isolated and characterized. The structures of these isolated compounds were determined to be (7S, 8S)-syringoylglycerol-9-O-(6'-O-cinnamoyl)-beta-D-glucopyranoside and (7S, 8S)-syringoylglycerol 9-O-beta-D-glucopyranoside by analysis of physical and spectroscopic data (FDMS, 1H NMR, 13C NMR, HMQC, and HMBC experiments) together with chemical syntheses.
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