A novel t(2;17) in transformation of essential thrombocythemia to acute myelocytic leukemia
Related Experiment Video
Updated: Aug 29, 2026

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
Published on: June 6, 2025
Vladimir Lj Lazarevic1, Dragica Tomin, Gradimir M Jankovic
1Institute of Hematology, Clinical Center of Serbia, Koste Todorovica 2 Street, Belgrade, Serbia, Yugoslavia. vladimir.lazarevic@vll.se
Abstract:
A transformation of essential thrombocythemia to acute myelocytic leukemia (AML), myelodysplastic syndrome, or agnogenic myelocytic metaplasia is a relatively rare event. It occurs in 1%-4.5% of all patients with either treated or untreated essential thrombocythemia. Cytogenetic changes in the transformation to AML are common. We report the case of a patient treated for essential thrombocythemia with hydroxyurea for 49 months. He developed AML with a t(2;17), which to our knowledge has not been described in the literature.
Related Concept Videos
Differentiation of Common Myeloid Progenitor Cells
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...