Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Animal models for intestinal tissue engineering.

M K Chen1, E A Beierle

  • 1Department of Surgery, University of Florida, Gainesville, FL 32610, USA. chenmk@surgery.ufl.edu

Biomaterials
|December 31, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Pediatric surgery for middle ear cholesteatoma: analysis of 47 cases].

Zhonghua yi xue za zhi·2024
Same author

Embryology and surgical anatomy of pediatric solid tumors.

Seminars in pediatric surgery·2022
Same author

[The study of smoking impact on autophagy in alveolar macrophages of human silicosis].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2020
Same author

Solute carrier family 12 member 5 promotes tumor invasion/metastasis of bladder urothelial carcinoma by enhancing NF-κB/MMP-7 signaling pathway.

Cell death & disease·2017
Same author

Unmet information needs and clinical characteristics in patients with precancerous oral lesions.

European journal of cancer care·2015
Same author

γ₁34.5-deleted HSV-1-expressing human cytomegalovirus IRS1 gene kills human glioblastoma cells as efficiently as wild-type HSV-1 in normoxia or hypoxia.

Gene therapy·2015

Tissue engineering offers a promising solution for short bowel syndrome, moving beyond transplantation. Regenerating neointestines using scaffolds in animal models shows potential for future therapeutic options.

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Gastroenterology

Background:

  • Short bowel syndrome (SBS) is debilitating, with intestinal transplantation facing limitations like morbidity and organ scarcity.
  • Current treatments, including total parenteral nutrition, manage but do not cure SBS.
  • The need for alternative therapies for SBS is critical.

Purpose of the Study:

  • To review the progress of intestinal bioengineering, focusing on animal models.
  • To explore the evolution of tissue engineering strategies for intestinal regeneration.
  • To assess the potential of tissue-engineered intestine as a future treatment for SBS.

Main Methods:

  • Review of studies utilizing autologous tissue patches for intestinal regeneration.

Related Experiment Videos

  • Analysis of research employing absorbable biomaterials as scaffolds for tissue ingrowth.
  • Examination of novel methods involving seeding cells onto resorbable scaffolds for neointestine creation.

    • Main Results:

    • Successful regeneration of various gastrointestinal segments, including esophagus, stomach, small bowel, and colon, has been demonstrated in animal models.
    • Early studies explored autologous tissue and biomaterial scaffolds for regeneration.
    • Novel approaches involve seeding cells onto scaffolds for in vivo neointestine development.

    Conclusions:

    • Tissue-engineered intestine shows significant promise as a future therapeutic option for patients with SBS.
    • While preliminary, animal model studies indicate the feasibility of regenerating functional intestinal tissue.
    • This field represents a new frontier in addressing the limitations of current SBS treatments.