Related Experiment Video
Updated: Aug 4, 2026

Screening Assay for Oxidative Stress in a Feline Astrocyte Cell Line, G355-5
Published on: July 13, 2011
Monoamine oxidase inhibition and CNS immunodeficiency infection
E Koutsilieri1, C Scheller, V ter Meulen
1Clinical Neurochemistry, National Parkinson Foundation Center of Excellence Research Laboratory, Department of Psychiatry and Psychotherapy, Julius-Maximilians-University, Füchsleinstr 15, 97080 Würzburg, Germany. eleni.koutsilieri@mail.uni-wuerzburg.de
Abstract:
HIV invades CNS subcortical areas, particularly the dopamine-rich basal ganglia and induces a subcortical dementia. Data suggest that the basal ganglia dysfunction plays a critical role in the neuropsychiatric manifestation of HIV infection. Therefore, therapeutic approaches for HIV dementia nowadays wish to include apart from the highly active antiretroviral therapy (HAART) also adjunctive medication. In this short article, we report briefly on neurotoxicity associated with the immunodeficiency virus and discuss the effects of selegiline, a monoamine oxidase inhibitor which enhances dopamine availability in CNS on immunodeficiency virus-induced neurological disease.
More Related Videos
09:38Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
Published on: September 12, 2016
08:49Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice
Published on: October 6, 2023
Related Concept Videos
Immunodeficiency Diseases
There are three main causes of immunodeficiency disorders...
Cryptococcal Meningitis