Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Amine oxidases and tumors.

P Pietrangeli1, B Mondovì

  • 1Department of Biochemical Sciences A Rossi Fanelli and CNR Centre of Molecular Biology, La Sapienza University of Rome, Ple Aldo Moro 5, 00185 Rome, Italy.

Neurotoxicology
|December 31, 2003
PubMed
Summary

Amine oxidases (AO) are linked to biogenic amine metabolism, influencing cell growth and cancer. Their products can inhibit cell growth, highlighting the importance of balancing oxidant and antioxidant enzymes in cancer regulation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inducible expression of maize polyamine oxidase in the nucleus of MCF-7 human breast cancer cells confers sensitivity to etoposide.

Amino acids·2007
Same author

Substrate specificity of copper-containing plant amine oxidases.

Journal of inorganic biochemistry·2007
Same author

Interaction of biologically active amines with mitochondria and their role in the mitochondrial-mediated pathway of apoptosis.

Current medicinal chemistry·2004
Same author

Biogenic amines and apoptosis: minireview article.

Amino acids·2004
Same author

Some new functions of amine oxidases.

Inflammopharmacology·2004
Same author

Is the catalytic mechanism of bacteria, plant, and mammal copper-TPQ amine oxidases identical?

Biochimica et biophysica acta·2003

Area of Science:

  • Biochemistry
  • Cell Biology
  • Oncology

Background:

  • The precise physiological roles of amine oxidases (AO) in living organisms remain under investigation.
  • AO activity is closely associated with biogenic amine metabolism, a process vital for cell growth and differentiation.
  • Previous studies suggest a correlation between the degree of tumor malignancy and altered AO activity levels.

Purpose of the Study:

  • To explore the multifaceted roles of amine oxidases in biological systems.
  • To investigate the implications of amine oxidase activity and its products in cell growth regulation and carcinogenesis.
  • To understand the significance of oxidant-antioxidant enzyme balance in cancer development.

Main Methods:

  • Literature review on amine oxidase function and biogenic amine metabolism.
  • Analysis of existing data correlating AO activity with tumor malignancy.
  • Examination of the cytotoxic and inhibitory effects of AO catalytic products (hydrogen peroxide, aminoaldehyde).

Main Results:

  • Amine oxidases are implicated in essential cellular processes, including growth and differentiation, via biogenic amine metabolism.
  • The cytotoxic products of amine oxidase activity, hydrogen peroxide and aminoaldehyde, act as cell growth inhibitors.
  • Biogenic amines can function as both cellular toxins and protective agents, depending on cellular context.

Conclusions:

  • A delicate balance between oxidant and antioxidant enzymes is crucial for regulating cell growth and appears to be a key factor in carcinogenesis.
  • Amine oxidases play a complex role in cellular physiology, with implications for cancer progression.
  • Further research into amine oxidase function is warranted to elucidate their full impact on health and disease.

Related Experiment Videos