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08:52
Generation of Murine Cardiac Pacemaker Cell Aggregates Based on ES-Cell-Programming in Combination with Myh6-Promoter-Selection
Published on: February 17, 2015
[Multiple myeloma with a mass formation in a pacemaker pocket].
M Sasaki1, Y Katoh, M Niwakawa
1Second Department of Internal Medicine, Shiga University of Medical Science.
[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|November 1, 1992
Summary
A rare plasmacytoma developed over a pacemaker pocket in a multiple myeloma patient. This tumor showed aggressive growth, highlighting potential risks associated with implanted devices.
Area of Science:
- Oncology
- Cardiology
- Medical Device Technology
Background:
- A 74-year-old female with multiple myeloma developed severe atrioventricular block requiring a pacemaker.
- The patient received a transvenous demand pacemaker with the pulse generator implanted subcutaneously.
Observation:
- A mass developed over the pulse generator pocket, diagnosed histologically as plasmacytoma.
- The tumor showed rapid regrowth after initial chemotherapy response.
- Systemic and maxillary tumors appeared, indicating disease progression.
Findings:
- The patient's multiple myeloma was characterized by specific plasma cell counts and IgA M protein levels.
- The plasmacytoma exhibited aggressive behavior, recurring quickly after treatment.
- The patient ultimately succumbed to cardiac failure.
Implications:
- This case highlights the potential for plasmacytoma development in the vicinity of implanted electronic device pockets.
- Further research is needed to understand the etiopathogenesis of device-associated plasmacytomas.
- Clinical vigilance is crucial for monitoring patients with implanted devices, especially those with underlying plasma cell dyscrasias.
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