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Updated: Aug 29, 2026

08:45
Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors
Published on: July 17, 2020
Discovery of novel PTP1b inhibitors
Denise A Ockey1, Thomas R Gadek
1Genentech, Inc., Department of Bioorganic Chemistry, One DNA Way, South San Francisco, CA 94080, USA. ockey@speakeasy.net
Bioorganic & Medicinal Chemistry Letters
|December 31, 2003
Abstract:
A small library of 19 compounds was designed based on unique structural features of PTP1b. Utilizing electrospray ionization mass spectrometry (ESI-MS) to provide binding information about complexes of enzyme and small molecule ligands, two classes of lead compounds were discovered.

