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Discovery of novel PTP1b inhibitors

Denise A Ockey1, Thomas R Gadek

  • 1Genentech, Inc., Department of Bioorganic Chemistry, One DNA Way, South San Francisco, CA 94080, USA. ockey@speakeasy.net

Bioorganic & Medicinal Chemistry Letters
|December 31, 2003
PubMed

Abstract:

A small library of 19 compounds was designed based on unique structural features of PTP1b. Utilizing electrospray ionization mass spectrometry (ESI-MS) to provide binding information about complexes of enzyme and small molecule ligands, two classes of lead compounds were discovered.

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