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The solid-phase conjugation of purpurin-18 with a synthetic targeting peptide
Ian Walker1, David I Vernon, Stanley B Brown
1Centre for Photobiology and Photodynamic Therapy, Department of Biochemistry and Molecular Biology, University of Leeds, LS2 9JT, Leeds, UK.
Bioorganic & Medicinal Chemistry Letters
|December 31, 2003
Abstract:
It has been demonstrated that efficient site-specific coupling of the highly active photodynamic therapy sensitiser purpurin-18 to the synthetic targeting peptide G-G-V-K-R-K-K-K-P-G-Y-G can be achieved with greater than 85% purity.
