Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell detachment method using shock-wave-induced cavitation.

L Junge1, C D Ohl, B Wolfrum

  • 1Department of Applied Physics, Physics of Fluids, University of Twente, Enschede, The Netherlands.

Ultrasound in Medicine & Biology
|December 31, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combined cyclosporine A and urolithin A therapy ameliorates murine lupus nephritis.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same author

Pathogenic Role of mTOR Signaling in Cardiometabolic Disease: Implications for Heart, Liver, and Kidney Dysfunction.

Physiological research·2025
Same author

Penetration of laser-induced jets into soft elastic substrates: simplified model and experiments.

Biomedical optics express·2025
Same author

Evidence based recommendations for health professionals to improve care of people with spinal cord injury and cognitive impairment: an update to the psychosocial care practice guide.

Spinal cord·2025
Same author

A Risk Profile Calculator for Anterior Cruciate Ligament (ACL) Reconstruction Surgery using a Novel Scoring System: The Multi-factorial ACL Target Score (MATS) Score.

Malaysian orthopaedic journal·2025
Same author

Lymph Node-Targeted Cyclosporine A Alleviates Myocarditis in Lupus Mice by Inhibiting CD68+ Macrophage-Driven Lymphangiogenesis.

Materials today (Kidlington, England)·2025
Same journal

Multidimensional Safety Assessment of a Low-Intensity Scanning Ultrasound (SUS) Protocol in Sheep.

Ultrasound in medicine & biology·2026
Same journal

Acoustic Characterization of a Modified IEC Agar-Based Tissue-Mimicking Material Across the 3.5-50 MHz Frequency Range.

Ultrasound in medicine & biology·2026
Same journal

Deep Learning-Based Standard Section Recognition and Multi-Organ Segmentation in Upper Abdominal Ultrasound.

Ultrasound in medicine & biology·2026
Same journal

Cardiac Natural Mechanical Wave Detection and Speed Estimation Using Deep Learning-Based 2-D Ultrasound Imaging: A Feasibility Study.

Ultrasound in medicine & biology·2026
Same journal

Region-Specific Evaluation of Plaque Segmentation in Cross-sectional Projections of Carotid Ultrasound Images Using Deep Learning Models in a Sub-clinical Atherosclerosis Cohort.

Ultrasound in medicine & biology·2026
Same journal

Simulating the Dedifferentiation Process of Thyroid Cancer: Insights from Mouse Models and Ultrasound Imaging.

Ultrasound in medicine & biology·2026
See all related articles

Shock waves cause HeLa cells to detach from surfaces by creating cavitation bubbles. The collapse of these bubbles generates high-speed flows, leading to cell detachment and offering controlled cell separation methods.

Area of Science:

  • Cell Biology
  • Biophysics
  • Fluid Dynamics

Background:

  • Adherent cell detachment is crucial for biological processes and research.
  • Current cell detachment methods have limitations in control and scalability.
  • Shock wave interactions with biological materials are not fully understood.

Purpose of the Study:

  • To analyze the detachment of adherent HeLa cells induced by shock waves.
  • To investigate the role of cavitation bubbles in shock wave-induced cell detachment.
  • To explore shock wave application as a controllable method for cell detachment.

Main Methods:

  • Utilized shock wave application on adherent HeLa cells.
  • Observed cell detachment using high-speed video recording.

Related Experiment Videos

  • Employed image-processing to reconstruct flow trajectories.
  • Estimated shear stress and detachment area using kinetic modeling.

    • Main Results:

    • Cell detachment strongly correlated with the spatial presence of cavitation bubbles.
    • Cavitation bubble collapse generates high-speed flow along the substrate.
    • This flow induces rapid detachment of HeLa cells.
    • Quantified shear stress and detachment area.

    Conclusions:

    • Shock wave-induced cavitation is a primary mechanism for HeLa cell detachment.
    • This method offers precise spatial and temporal control over cell detachment.
    • Shock waves present a novel, controllable approach to cell detachment techniques.