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Updated: Jul 9, 2026
Metabolic Glycoengineering of Sialic Acid Using N-acyl-modified Mannosamines
Published on: November 25, 2017
The effect of polysialic acid on molecular dynamics of model membranes studied by 31P NMR spectroscopy
Anna Timoszyk1, Zofia Gdaniec, Lidia Latanowicz
1Department of Biophysics, Institute of Biotechnology and Environmental Science, University of Zielona Góra, Podgórna 50, 65-246, Poland. a.timoszyk@ibos.uz.zgora.pl
Abstract:
The paper reports the results of our study on the dynamics of model phospholipid membranes studied by 31P NMR spectroscopy. The 31P NMR spectra of multilamellar vesicles in temperatures below the main phase transition of PC are reported. The 31P NMR spectra revealed changes caused by an increase of the membrane fluidity when polysialic acid (polySia) was applied as a modifying agent. The presence of polySia in the external environment of the phospholipid vesicles changes the motional freedom in the region of phosphate group of lipids. Increase of polysialic acid concentration changes structural properties of a membrane by increasing its fluidity.
