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Updated: Jun 24, 2026
Method of Direct Segmental Intra-hepatic Delivery Using a Rat Liver Hilar Clamp Model
Published on: April 2, 2017
Hepatoprotective effect of allicin on tissue defense system in galactosamine/endotoxin challenged rats
Veereshwarayya Vimal1, Thiruvengadam Devaki
1Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai, 600 025, Tamil Nadu, India. veereshwar_v@yahoo.com
Abstract:
Allicin (diallythiosulfinate) is the main biologically active component of freshly crushed garlic (Alliaceae Allium sativum Linn.) cloves. It is produced by the interaction of the non-protein amino acid alliin with the enzyme alliinase (alliin lyase, EC 4.4.1.4). D-Galactosamine highly sensitizes the host response of the experimental animal to endotoxin (lipopolysaccharide) and causes fulminant hepatitis within 8h after administration. In D-galactosamine/lipopolysaccharide (D-GalN/LPS)-induced hepatitis rats, a significant increase of lipid peroxidation and decreased liver antioxidant enzyme levels are observed. Pretreatment with allicin, the active component of freshly crushed garlic cloves, prevented these alterations.
