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Updated: Aug 29, 2026

Dithranol as a Matrix for Matrix Assisted Laser Desorption/Ionization Imaging on a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer
Published on: November 26, 2013
A high pressure matrix-assisted laser desorption ion source for Fourier transform mass spectrometry designed to
Peter B O'Connor1, Bogdan A Budnik, Vera B Ivleva
1Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA. poconnor@bu.edu
Abstract:
A new design for a high pressure MALDI-FTMS instrument is described and initial data are shown. The instrument incorporates a large, 10 cm x 10 cm, sample translation stage to accommodate and position the MALDI target. The new instrument allows coupling to a wide variety of surface techniques such as gel electrophoresis or surface plasmon resonance. Coupling to thin layer chromatography is shown. Furthermore, a new nozzle design allows high pressure collisional cooling sufficient to stabilize gangliosides while minimizing the gas load on the system.
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