Dual-stimuli-responsive hydrogels based on poly(N-isopropylacrylamide)/chitosan semi-interpenetrating networks
Liliana Verestiuc1, Claudia Ivanov, Eugen Barbu
1Faculty of Medical Bioengineering, University of Medicine and Pharmacy Gr. T. Popa, 16 Universitatii St., Iasi 6600, Romania.
Abstract:
The synthesis and characterisation of semi-interpenetrating polymeric networks obtained by the radical-induced polymerisation of N-isopropylacrylamide in the presence of chitosan using tetraethyleneglycoldiacrylate as the crosslinker is described. The influence of the degree of crosslinking and that of the ratio of chitosan to poly(N-isopropylacrylamide) on the "pH/temperature induced" phase transition behaviour and swelling characteristics of the hydrogel system are investigated. The ability of the same system to act as a controlled release vehicle for pilocarpine hydrochloride is evaluated.
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