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Updated: Aug 29, 2026

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
Published on: May 16, 2019
Compliance and satisfaction with switching from an immediate-release to sustained-release formulation of valproate in
Julie Doughty1, Gus A Baker, Ann Jacoby
1Centre for Health Services Research, University of Newcastle upon Tyne, Newcastle upon Tyne, UK.
Objective:
The goal of our work was to assess compliance and patient satisfaction with switching from sodium valproate to Depakine Chrono in patients with epilepsy.
Methods:
Clinical, demographic, and behavioral details assessing compliance and satisfaction were collected using self-completion questionnaires at the time of inclusion in the study and 3 months after the inclusion day.
Results:
Data were collected from 2031 respondents from eight European countries. There were significant differences between time 1 and time 2 of the study in seizure frequency, reported side effects, compliance, and patient satisfaction.
Conclusion:
Findings suggest that switching from sodium valproate to Depakine Chrono results in an increase in seizure-free rates, a reduction in reported side effects, an improvement in the level of compliance, and a modest improvement in patient satisfaction.
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