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The folate receptor as a molecular target for tumor-selective radionuclide delivery

Chun-Yen Ke1, Carla J Mathias, Mark A Green

  • 1Department of Industrial and Physical Pharmacy, Purdue University, West, Lafayette, IN 47907-2091, USA.

Nuclear Medicine and Biology
|December 31, 2003
PubMed

Insights

The folate receptor on cell membranes shows promise for targeting tumors with drugs. Radiolabeled folate conjugates are being explored for cancer imaging and therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Radiochemistry

Background:

  • The cell-membrane folate receptor is overexpressed in various tumors.
  • This receptor presents a target for selective cancer therapies.
  • Folate-chelate conjugates can be labeled with radioisotopes for imaging.

Purpose of the Study:

  • To review the folate receptor as a molecular target for drug delivery.
  • To survey the literature on tumor-targeting using radiolabeled folate-chelate conjugates.

Main Methods:

  • Literature review of folate receptor targeting strategies.
  • Survey of studies utilizing radiolabeled folate-chelate conjugates.

Main Results:

  • The folate receptor is a viable target for tumor-selective drug delivery.
  • Radiolabeled folate-chelate conjugates have been investigated for diagnostic imaging.

Conclusions:

  • The folate receptor is a promising target for developing novel cancer therapeutics and diagnostics.
  • Further research into radiolabeled folate conjugates could enhance tumor visualization and treatment.

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