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Breast sentinel lymph node mapping at CT lymphography with iopamidol: preliminary experience
Kazuyoshi Suga1, Yue Yuan, Munemasa Okada
1Department of Radiology, Yamaguchi University School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan. sugar@po.cc.yamaguchi-u.ac.jp
Radiology
|December 31, 2003
Summary
Computed tomographic (CT) lymphography effectively maps sentinel lymph nodes (SLNs) in breast cancer patients. This technique aids in precisely locating SLNs for biopsy, improving surgical guidance.
Area of Science:
- Radiology
- Oncology
- Surgical Pathology
Background:
- Sentinel lymph node biopsy is crucial for breast cancer staging.
- Accurate identification of sentinel lymph nodes (SLNs) is essential for effective staging and treatment planning.
Purpose of the Study:
- To assess the utility of interstitial computed tomographic (CT) lymphography using iopamidol for sentinel lymph node (SLN) mapping in breast cancer patients.
- To evaluate CT lymphography as a guidance tool for SLN biopsy.
Main Methods:
- 17 patients with operable breast cancer underwent multi-detector row helical CT.
- Subcutaneous injection of 2 mL undiluted iopamidol into peritumoral and periareolar areas followed by massage.
- CT lymphography was used to assess SLN location and size, compared with standard axillary lymph node dissection and blue dye staining.
Main Results:
- CT lymphography successfully localized SLNs in all patients by visualizing afferent lymphatic vessels.
- A single axillary SLN was identified in most cases; some patients had multiple SLNs.
- CT lymphographic guidance facilitated the intraoperative identification of SLNs, including those not stained by blue dye.
Conclusions:
- Preoperative CT lymphography-guided SLN mapping provides detailed lymphatic anatomy and precise SLN localization.
- This technique shows promise as a valuable tool for directing sentinel lymph node biopsy in breast cancer management.