In vitro analysis of AcrySof intraocular lens glistening

The authors studied the effects of changes in packaging solution temperature on the development of glistening in acrylic intraocular lenses (AcrySof, Alcon).

Glistening was examined by slit lamp at each condition. In Experiment 1, AcrySof lenses were soaked in physiologic saline adjusted to 15 degrees C and 37 degrees C in an incubator. In Experiment 2, AcrySof lenses were soaked in physiologic saline adjusted to 37 degrees C and 60 degrees C for 5 min, then stored in physiologic saline adjusted to 15 degrees C. In Experiment 3, glistening formation was induced in AcrySof lenses by soaking them in warm water (37 degrees C). The lenses were allowed to dry at 15 degrees C and then soaked in physiologic saline adjusted to 15 degrees C. After storage of dry AcrySof lenses at 37 degrees C in an incubator for 10 months followed by soaking in physiologic saline adjusted to 15 degrees C, glistening formation was evaluated in Experiment 4.

Glistening became observable after 1 month, despite the temperature having been lowered to 15 degrees C. No glistening was observed in the lenses soaked in physiologic saline adjusted to 37 degrees C after 5 min, but glistening was observed 1 month after soaking. When allowed to dry at 15 degrees C, the glistening decreased. After 1 month of soaking at 15 degrees C, glistening was again observable.

AcrySof lenses soaked in warm water for a short time may change characteristics, and therefore, close monitoring of the temperature and time of soaking is necessary to prevent glistening formation.