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Childhood Helicobacter pylori infection, clinical presentations, endoscopic, histologic features and results of
1Gastroenterology and Nutrition Unit, Queen Sirikit National Institute of Child Health, Bangkok 10400, Thailand.
Insights
Helicobacter pylori infection is common in Thai children, with vomiting and epigastric pain as leading symptoms. Treatment involved antibiotics and acid suppressors.
Area of Science:
- Pediatric Gastroenterology
- Infectious Diseases
- Microbiology
Background:
- Helicobacter pylori (H. pylori) infection is a significant global health concern.
- Childhood H. pylori infections present with diverse clinical manifestations and require specific diagnostic approaches.
Purpose of the Study:
- To investigate the clinical features, endoscopic and histologic findings, and treatment outcomes of childhood H. pylori infections.
- To determine the prevalence of H. pylori in symptomatic children in Thailand.
Main Methods:
- A retrospective study of 144 pediatric patients undergoing upper GI endoscopy.
- H. pylori diagnosis confirmed by positive urease test and/or organism identification in biopsy specimens.
- Data collected on clinical presentation, endoscopic findings, histology, and treatment regimens.
Main Results:
- H. pylori infection was confirmed in 15.3% (22/144) of pediatric patients.
- Vomiting and epigastric pain were the most frequent symptoms.
- Common findings included gastric inflammation, nodular hyperplasia, and chronic gastritis/gastroduodenitis.
Conclusions:
- H. pylori infection is a prevalent issue among symptomatic children in Thailand.
- The study highlights the association between H. pylori and gastrointestinal symptoms in pediatric populations.
- Further research is needed to establish definitive links between infection, symptoms, and endoscopic/histologic findings.
Objective:
To study childhood Helicobacter pylori infection concerning the clinical presentations, endoscopic, histologic features and results of treatment.
Material And Method:
A retrospective study conducted at the Gastroenterology and Nutrition Unit, Queen Sirikit National Institute of Child Health (QSNICH) was done from January 1993 to December 2002. All patients presented with recurrent abdominal pain, upper GI bleeding (non-variceal bleeding) chronic vomiting and dyspeptic symptoms who underwent upper GI endoscopy were included in this study. Positive urease test verified by biopsied specimens from the gastric antrum and body and/or finding the organisms from the specimens were the criteria for diagnosis of H. pylori infection. Clinical presentations, endoscopic, histologic features and results of treatment in H. pylori infected cases were described.
Result:
A total of 144 patients who underwent upper GI endoscopy were included in the study. 22 out of 144 cases proved to be infected by H. pylori. Ages ranged from 2.6 to 14 years (mean age 9 years). The male/female ratio was 1:1.2. Vomiting and epigastric pain were the leading symptoms. Endoscopic findings were divided into inflammation in the stomach 12 cases, both stomach and duodenum 6 cases and duodenal ulcer 4 cases. Nodular hyperplasia of gastric antrum was found in 8 out of 22 cases. Histologic evidence of chronic gastritis was present in 12 cases, chronic gastroduodenitis 6 cases and chronic duodenitis in duodenal ulcer cases. Treatment regimen consisted of one H2 blocker (ranitidine) initially which was changed to omeprazole in 2001 combined with 2 antibiotics (amoxycillin and metronidazole) for 14 days.
Conclusion:
This study group represented middle and low income groups from around Bangkok and many parts of Thailand. The prevalence of H. pylori infection in the present study was 15.3 per cent which reflects that H. pylori infection is a common health problem in Thailand. However, because this was only a descriptive study, the authors cannot specify the association between symptoms, endoscopic findings, histologic features and disease.
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