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Milbemycin alpha17 and related compounds synthesized from milbemycin A4: synthetic procedure and acaricidal
Takahiro Tsukiyama1, Ayako Kinoshita, Reiji Ichinose
1Agroscience Research Laboratories, Sankyo Agro Co., Ltd. 894 Yasu, Yasu-cho, Yasu-gun, Shiga 520-2342, Japan. tukiya@sankyo-agro.co.jp
Abstract:
Milbemycin alpha17, a 14-demethyl congener of milbemycin A4, has been reported as a natural product. In this paper, we report the successful development of a chemical derivation method to synthesize milbemycin alpha17 from milbemycin A4, as well as our use of a similar method to prepare 24-demethylmilbemycin A4 from the same precursor. The acaricidal activities of these compounds were assessed against the organophosphorus-sensitive two-spotted spider mites (Tetranychus urticae) on the primary leaves of cowpea plants (Vigna sinesis Savi species) by spraying.
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