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Related Concept Videos

Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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The Cell Cycle Control System01:28

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The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
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The Cell Cycle Control System02:11

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The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
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Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
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Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

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Cell-cycle targeted therapies.

Charles Swanton1

  • 1Royal Marsden Hospital Breast Unit, Royal Marsden Hospital NHS Trust, London, UK. RobertCharles.Swanton@rmh.nthames.nhs.edu

The Lancet. Oncology
|January 1, 2004
PubMed
Summary
This summary is machine-generated.

The cell cycle controls eukaryotic cell division using protein families like cyclins and cyclin-dependent kinases. Aberrations in these cell cycle regulators are common in human cancers, leading to new drug development.

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Area of Science:

  • Cell Biology
  • Molecular Oncology

Background:

  • Eukaryotic cell division is governed by a conserved cell cycle.
  • Key regulators include cyclin D/E and cyclin-dependent kinases (CDKs).
  • Dysregulation of cell cycle proteins is frequent in human tumors.

Purpose of the Study:

  • To review cell cycle regulatory protein families.
  • To discuss their role in cancer progression.
  • To highlight pharmacological strategies targeting the cell cycle.

Main Methods:

  • Literature review of cell cycle regulation.
  • Analysis of protein family functions.
  • Examination of aberrations in cancer.
  • Overview of therapeutic approaches.

Main Results:

  • Cyclin D/E and CDKs drive cell cycle transition via retinoblastoma protein phosphorylation.
  • Two inhibitor families restrain cyclin/CDK activity.
  • Understanding these mechanisms informs cancer therapy.

Conclusions:

  • Targeting cell cycle regulators offers potential for cancer treatment.
  • Further research into cell cycle control is crucial for developing novel cancer drugs.