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Related Experiment Videos

Multiple signaling pathways and a selector protein sequentially regulate Drosophila wing development.

Shian-Jang Yan1, Yi Gu, Willis X Li

  • 1Department of Biology, University of Rochester, Rochester, NY 14627, USA.

Development (Cambridge, England)
|January 1, 2004
PubMed
Summary
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Drosophila wing development relies on precise gene regulation. A specific DNA region controls Serrate gene expression, integrating signals from key pathways like Notch and Wingless for proper organogenesis.

Area of Science:

  • Developmental Biology
  • Genetics
  • Molecular Biology

Background:

  • Drosophila wing development is a model for organogenesis.
  • Selector genes and cell signaling molecules are crucial for development.
  • Understanding the integration of signaling pathways and selector proteins is key.

Purpose of the Study:

  • To investigate the regulatory network controlling Serrate (Ser) gene expression.
  • To elucidate how multiple signaling pathways and selector proteins integrate during wing development.
  • To analyze the function of a specific cis-regulatory element in Ser expression.

Main Methods:

  • Characterization of a 794 bp cis-regulatory element from the Ser gene.
  • Analysis of endogenous Ser expression patterns during Drosophila wing development.

Related Experiment Videos

  • Investigating the roles of Apterous (Ap), Notch (N), Wingless (Wg), and Egfr signaling pathways.

    • Main Results:

    • A 794 bp cis-regulatory element recapitulates endogenous Ser expression patterns.
    • Ap, N, and Wg signaling pathways sequentially regulate Ser expression via the enhancer.
    • Egfr pathway controls later Ser expression in vein progenitor cells.

    Conclusions:

    • A cis-regulatory element integrates multiple signaling pathways and a selector protein during Drosophila wing development.
    • This regulatory mechanism is potentially conserved in appendage development across arthropods and vertebrates.