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Allergen specific immunotherapy in nasobronchial allergy.
S V Joshi1, D M Tripathi, H L Dhar
1Medical Research Centre, Bombay Hospital Trust, Mumbai - 400 020, India.
Indian Journal of Medical Sciences
|January 1, 2004
Summary
Multiple antigen immunotherapy effectively treats nasobronchial allergies. This approach, using up to six allergens, shows results comparable to single allergen treatments for allergic rhinitis and asthma.
Area of Science:
- Immunology
- Allergology
- Clinical Medicine
Background:
- Multiple antigens have been explored for immunotherapy in allergic disorders with varied outcomes.
- Previous studies have utilized fewer than five antigens, yielding inconsistent results.
Purpose of the Study:
- To assess the efficacy of immunotherapy using up to six antigens for nasobronchial allergy.
- To evaluate the impact of multiple allergen immunotherapy on patients with allergic rhinitis and asthma.
Main Methods:
- 131 patients with allergic disorders (56 rhinitis, 75 asthma) meeting specific criteria (≥3 years symptoms, IgE-mediated, failed avoidance, moderate-to-severe) received multiple allergen immunotherapy for one year.
- Standardized allergen extracts were used, and patients with secondary allergic conditions were excluded.
- Statistical analysis employed Student's t-test.
Main Results:
- Significant improvements were observed in Peak Expiratory Flow Rate (PEFR).
- A reduction in skin sensitivity to the immunotherapy allergens was noted.
- Patients experienced symptomatic relief without adverse reactions.
Conclusions:
- Multiple allergen immunotherapy is a safe and effective treatment for nasobronchial allergy.
- The efficacy of multiple allergen immunotherapy is comparable to that of monoallergen immunotherapy.
- This study supports the use of multiple allergens in immunotherapy for allergic rhinitis and asthma.