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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Absence of factor V Leiden (G1691A) mutation, FII G20210A allele in coronary artery disease in North India
1Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rai Bareilly Road, Lucknow - 226 014, India.
Insights
Factor V Leiden mutation and FII G20210A polymorphism were absent in North Indian populations, indicating they are not independent risk factors for coronary artery disease (CAD) or myocardial infarction in this group.
Area of Science:
- Cardiovascular Genetics
- Thrombosis Research
Background:
- Coronary artery diseases (CADs) result from complex interactions between genetic and environmental factors.
- Factor V Leiden mutation (FVL) and FII G20210A polymorphism are linked to venous thrombosis but their role in CAD is uncertain.
Purpose of the Study:
- To investigate the association of FVL and FII G20210A polymorphisms with CAD in a North Indian population.
- To determine if these genetic factors are independent risk factors for myocardial infarction.
Main Methods:
- A case-control study involving 200 patients with angiographically proven CAD and 200 age- and sex-matched controls from North India.
- Genotyping for Factor V Leiden mutation and FII G20210A polymorphism was performed.
Main Results:
- Both Factor V Leiden mutation and FII G20210A polymorphism were found to be completely absent in the studied North Indian population.
- Consequently, these genetic variants could not be established as independent risk factors or predictors for CAD in this cohort.
Conclusions:
- The studied polymorphisms (FVL and FII G20210A) are not independent risk factors for CAD or myocardial infarction in the North Indian population.
- Further research is recommended to validate these findings in diverse Indian populations, given reported variations in FVL incidence elsewhere.
Background:
Interaction between various genetic and environmental factors is associated with coronary artery diseases (CADs). Factor V Leiden mutation (FVL) and FII G20210A polymorphism are two recently described genetic factors with a propensity towards venous thrombosis, however, with a doubtful role in coronary artery disease and myocardial infarction.
Aim:
Present study was conducted to assess the relationship of both these factors in coronary artery disease in population from North India.
Setting And Design:
Case control study.
Material And Methods:
Two hundred angiographically proven coronary artery disease patients were studied to examine the association of Factor V Leiden mutation and FII G20210A mutation with coronary artery disease and myocardial infarction. Out of 200 patients, 51 had myocardial infarction. Two hundred controls were selected who were from north India and were also age and sex matched.
Results And Conclusions:
Our results indicate that both these polymorphisms were totally absent in our population, therefore, these variants cannot be considered as independent risk factors or as a predictor for CAD. However, there is a need to confirm the above findings on patients from different populations from different parts of the country as there are reports which show that the incidence of Factor V Leiden varies from 1.3 % to 10%.
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