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Experimental Corynebacterium pseudotuberculosis mastitis in dairy cows
1School of Veterinary Medicine, Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel.
The Veterinary Record
|January 2, 2004
Summary
Bovine mastitis was induced by Corynebacterium pseudotuberculosis, causing severe pyogranulomatous inflammation and anemia. Clinical signs included fever, reduced milk production, and persistent anemia in affected cows.
Area of Science:
- Veterinary Medicine
- Animal Pathology
- Microbiology
Background:
- Bovine mastitis is a significant economic concern in dairy farming.
- Corynebacterium pseudotuberculosis is a known pathogen capable of causing various infections in animals.
Purpose of the Study:
- To investigate the pathological effects of Corynebacterium pseudotuberculosis inoculation in dairy cows.
- To characterize the clinical and hematological changes associated with experimental bovine mastitis.
Main Methods:
- Three cows were inoculated with 2000 colony-forming units of Corynebacterium pseudotuberculosis into a teat canal.
- Hematological parameters (hematocrit, hemoglobin, red blood cell count) and clinical signs were monitored.
- Postmortem examinations and bacterial cultures were performed.
Main Results:
- Severe, chronic, pyogranulomatous mastitis developed in inoculated quarters.
- Anemia (normocytic, normochromic, non-regenerative) and neutrophilia were observed within days, followed by a regenerative response.
- Clinical signs included fever, cessation of milk production, and extensive mastitis lesions.
Conclusions:
- Corynebacterium pseudotuberculosis can induce severe mastitis and systemic illness in cows.
- The study highlights the pathological progression and hematological impact of this specific mastitis model.
- Effective treatment strategies for C. pseudotuberculosis mastitis require further investigation.