Related Experiment Video
Updated: Aug 29, 2026

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
Published on: June 27, 2025
Blood pressure control and left ventricular hypertrophy in long-term CAPD and hemodialysis patients: a
Ali Ihsan Günal1, Erdogan Ilkay, Ercan Kirciman
1Department of Nephrology, Firat University Medical School, Elazig, Turkey. igunal@yahoo.com
Insights
Hypertension and left ventricular hypertrophy (LVH) are similar in continuous ambulatory peritoneal dialysis (CAPD) and hemodialysis (HD) patients. Strict volume and blood pressure control are key to achieving comparable cardiac outcomes in both dialysis modalities.
Area of Science:
- Nephrology
- Cardiology
- Internal Medicine
Background:
- The prevalence of hypertension and left ventricular hypertrophy (LVH) in patients undergoing continuous ambulatory peritoneal dialysis (CAPD) versus hemodialysis (HD) remains unclear.
- Assessing cardiac structure and function differences between dialysis modalities is crucial for patient management.
Purpose of the Study:
- To compare cardiac performance indices between patients on CAPD and HD.
- To investigate the long-term effects of dialysis modality on cardiac parameters.
Main Methods:
- Compared cardiac performance in 50 HD patients and 34 CAPD patients.
- Subdivided patients into long-term (over 60 months) HD and CAPD groups for further analysis.
- Evaluated parameters including blood pressure, cardiothoracic index, left atrial index, left ventricular chamber size, wall thickness, left ventricular mass index (LVMI), and isovolumic relaxation time (IVRT).
Main Results:
- No significant differences in blood pressure or cardiothoracic index were observed between CAPD and HD patients.
- Left ventricular mass index (LVMI) and chamber dimensions were similar in both groups.
- No significant differences in cardiac structure or function were found between long-term HD and CAPD subgroups.
Conclusions:
- Continuous ambulatory peritoneal dialysis (CAPD) and hemodialysis (HD) have comparable effects on cardiac structure and function.
- Achieving normovolemia and normotension through strict volume control is essential for similar cardiac outcomes.
- Antihypertensive drug use may influence observed differences, highlighting the importance of volume management.
Background:
It is still not clear whether hypertension and left ventricular hypertrophy (LVH) are more common in continuous ambulatory peritoneal dialysis (CAPD) than in hemodialysis (HD) patients.
Methods:
To examine this subject, the indices of cardiac performance were compared between 50 HD and 34 CAPD patients. Patients were further divided into two subgroups [long-term (L) CAPD and L-HD] according to dialysis modality and duration of dialysis (more than 60 months' duration).
Results:
The blood pressure and cardiothoracic index of CAPD patients did not differ from HD patients. On average, the left atrial index was 2 mm/m2 higher in HD patients than in CAPD patients. Left ventricular chamber sizes, wall thickness, and left ventricular mass index (LVMI) in patients on CAPD were similar to those of HD patients. Isovolumic relaxation time (IVRT) of CAPD patients was insignificantly less than that of HD patients (101 +/- 22 and 115 +/- 27 msec respectively). There was no significant difference between the two subgroups (L-HD and L-CAPD) in blood pressure, left atrial diameter, left ventricular chamber size, wall thickness, LVMI, ejection fraction, or IVRT.
Conclusion:
If normovolemia and normotension are obtained by strict volume control without using antihypertensive drugs, the effects of the two modalities of chronic dialysis treatment (HD and CAPD) on cardiac structure and function are not different from each other.
Related Concept Videos
Hypertension and Regulation of Blood Pressure
Heart Failure II: Pathophysiology
Heart Failure VI: Adjunct Therapies
Hypertension III: Clinical Manifestations and Diagnostic Studies
Heart Failure V: Medical Management
Cardiomyopathy III: Hypertrophic Cardiomyopathy