Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Losartan induced fetal toxicity.

Bonilla Nayar1, Ashwani Singhal, Rajiv Aggarwal

  • 1Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

Indian Journal of Pediatrics
|January 2, 2004
PubMed
Summary

Losartan exposure during pregnancy may cause fetal toxicity, including skull bone ossification issues and kidney problems in newborns. This highlights the need for caution when prescribing angiotensin II receptor antagonists during gestation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence and Determinants of Female Sexual Dysfunction, and Its Association With Neurotrophic Biomarkers in Gynaecological Cancer Survivors: A Cross-Sectional Study.

Cancer control : journal of the Moffitt Cancer Center·2026
Same author

Endometrial Stromal Sarcoma With Tumor Thrombus: A Rare Manifestation.

The journal of obstetrics and gynaecology research·2026
Same author

Type 2 diabetes and obesity in South Asian patients with polyendocrine metabolic ovarian syndrome: The emerging role of metabolomics.

Best practice & research. Clinical endocrinology & metabolism·2026
Same author

Live surgical workshops: Balancing patient care and professional development.

The National medical journal of India·2026
Same author

Efficacy of an Extended 10-day Letrozole Regimen Compared to the 5-day Regimen in Enhancing Ovulation in Infertile Women with Polycystic Ovary Syndrome: A Randomised Controlled Trial.

Journal of human reproductive sciences·2026
Same author

Comparison of the Effect of Ketofol and Ketodex as Procedural Sedation and Analgesia for Oocyte Retrieval during <i>In vitro</i> Fertilisation Procedures: A Randomised Controlled Pilot Study.

Journal of human reproductive sciences·2026

Area of Science:

  • Pharmacology
  • Teratology
  • Neonatal Medicine

Background:

  • Angiotensin II receptor antagonists (ARAs) like losartan are used to treat hypertension.
  • While angiotensin converting enzyme (ACE) inhibitors are known teratogens, data on losartan's fetal effects is limited.
  • This study investigates potential fetal toxicity associated with in-utero losartan exposure.

Observation:

  • A case report details a newborn exposed to losartan in utero.
  • The infant presented with specific adverse effects post-birth.
  • These effects were monitored and documented.

Findings:

  • The newborn exhibited incomplete ossification of skull bones.
  • Transient oliguria (reduced urine output) was observed.
  • The infant also showed feed intolerance, impacting nourishment.

Related Experiment Videos

Implications:

  • This case suggests potential teratogenic risks of losartan, particularly affecting fetal bone development and renal function.
  • Healthcare providers should exercise caution when prescribing losartan during pregnancy.
  • Further research is warranted to fully elucidate the fetal safety profile of losartan and other ARAs.