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A new synthesis of lysergic acid
James B Hendrickson1, Jian Wang
1Department of Chemistry, Brandeis University, Waltham, Massachusetts 02454-9110, USA. hendrickson@brandeis.edu
Organic Letters
|January 3, 2004
Abstract:
[reaction: see text] (+/-)-Lysergic acid has been synthesized via an economical 8-step route from 4-bromoindole and isocinchomeronic acid without the need to protect the indole during the synthesis. Initial efforts to form the simpler 3-acylindole derivatives first and then cyclize these were unsuccessful in the cyclization step.