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Facile synthesis, aggregation behavior, and cholesterol solubilization ability of avicholic acid
Samrat Mukhopadhyay1, Uday Maitra
1Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, India.
Organic Letters
|January 3, 2004
Abstract:
[reaction: see text] Avicholic acid, a major constituent of the bile of several avian species, was synthesized in eight steps from readily available chenodeoxycholic acid in 9% overall yield using Breslow's remote functionalization strategy in a key step. Micelle formation and equilibrium cholesterol solubilization properties were studied for avicholate in aqueous solution.