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Updated: Aug 29, 2026

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells
Published on: January 23, 2018
Current state of and outlook for organogenesis from undifferentiated cells
Makoto Asashima1, Koji Okabayashi
1Graduate School of Arts and Sciences, University of Tokyo, Tokyo, Japan. asashi@bio.c.u-tokyo.ac.jp
Purpose:
The aims of regenerative medicine and artificial internal organ development are, respectively, to regenerate and provide for transplant tissue or organs.
Methods:
We summarize recent research on tissue differentiation and organogenesis using stem cells and report our laboratory's research using amphibian undifferentiated cells.
Results:
We have successfully induced differentiation in cells from Xenopus laevis and generated structures in vitro that function in a similar way to organs when transplanted to Xenopus and newt embryos. We are attempting to establish a system to induce sensory organs, including eyes.
Conclusion:
Our experimental systems in amphibians are useful for organogenetic research, and it is hoped that our techniques can, in the future, be applied to mammals.
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