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Updated: Aug 29, 2026
Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
Published on: October 16, 2013
Evaluation of interaction between gabapentin and baclofen in the formalin test in mice
Mirosław Czuczwar1, Jacek Kiś, Jarogniew Łuszczki
1Second Department of Anesthesiology and Intensive Therapy, Medical University, Staszica 16, PL 20-081 Lublin, Poland.
Abstract:
Gabapentin and baclofen at doses not affecting motor performance, produced dose-dependent inhibition of both phases in the formalin test in mice. Isobolographic analysis revealed an additive interaction between the studied drugs in the second phase of the formalin test. Gabapentin given at doses effective in both phases of the formalin test significantly potentiated baclofen-induced motor impairment.
