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Translational research in immunology: Japanese perspectives.
1Research Center for Allergy and Immunology, The Institute of Physical and Chemical Research, 1-7-22 Suehirocho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. rtriendl@rcai.riken.go.jp
Nature Reviews. Immunology
|January 6, 2004
Summary
Japan has a strong history in immunology research, but translating these discoveries into new therapies has been less successful. Further efforts are needed to bridge the gap between research and clinical application in Japan.
Area of Science:
- Immunological research
- Investigative medical research
- Translational medicine
Background:
- Japan boasts a rich legacy in immunology, pioneered by figures like Shibasaburo Kitasato.
- Japanese immunologists have contributed significantly to forefront discoveries in the field.
- Historically, the nation has excelled in basic research and combating infectious diseases.
Purpose of the Study:
- To analyze Japan's historical contributions to immunological research.
- To evaluate the translation of Japanese immunological discoveries into clinical applications and therapies.
- To identify potential challenges and opportunities in advancing translational immunology in Japan.
Main Methods:
- Historical review of immunological research in Japan.
- Analysis of key discoveries and their clinical impact.
- Comparative assessment of research output versus therapeutic innovation.
Main Results:
- Significant historical contributions to fundamental immunology are evident.
- The translation of immunological research into clinical therapies appears modest.
- A disparity exists between Japan's research prowess and its therapeutic innovation record.
Conclusions:
- Japan possesses a strong foundation in immunological research.
- There is a need to enhance the translation of research findings into tangible clinical benefits.
- Future strategies should focus on bridging the gap between discovery and application in Japanese immunology.