Related Experiment Video
Updated: Jul 19, 2026

Live Imaging Assay for Assessing the Roles of Ca2+ and Sphingomyelinase in the Repair of Pore-forming Toxin Wounds
Published on: August 25, 2013
PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide
Rolf Göggel1, Supandi Winoto-Morbach, Gabriele Vielhaber
1Research Center Borstel, Leibniz Center for Medicine and Biosciences, 23845 Borstel, Germany.
Abstract:
Platelet-activating factor (PAF) induces pulmonary edema and has a key role in acute lung injury (ALI). Here we show that PAF induces pulmonary edema through two mechanisms: acid sphingomyelinase (ASM)-dependent production of ceramide, and activation of the cyclooxygenase pathway. Agents that interfere with PAF-induced ceramide synthesis, such as steroids or the xanthogenate D609, attenuate pulmonary edema formation induced by PAF, endotoxin or acid instillation. Our results identify acid sphingomyelinase and ceramide as possible therapeutic targets in acute lung injury.
Related Concept Videos
Phosphoinositides and PIPs
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
IP3/DAG Signaling Pathway
Cerebral Edema ll: Pathophysiology
Chronic Obstructive Pulmonary Disease II: Emphysema
Pulmonary Edema II: Pathophysiology

