Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Tissue typing in perforating corneal transplantation].

J Wachtlin1, R Khaireddin, F Hoffmann

  • 1Augenklinik, Charité, Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin. wachtlin@ukbf.fu-berlin.de

Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft
|January 6, 2004
PubMed
Summary

Optimizing corneal transplantation requires moving beyond simple HLA matching. Advanced strategies considering non-MHC antigens and specific mismatch types improve graft allocation and reduce immune rejection.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Heart rate and heart rate variability of dairy cows with or without local anesthesia.

JDS communications·2026
Same author

Cardiopulmonary deconditioning and plasma volume loss are not sufficient to provoke orthostatic hypertension.

Hypertension research : official journal of the Japanese Society of Hypertension·2024
Same author

Characteristics and special challenges of neonatal emergency transports.

Early human development·2024
Same author

Impact of daily artificial gravity on autonomic cardiovascular control following 60-day head-down tilt bed rest.

Frontiers in cardiovascular medicine·2023
Same author

Effects of daily artificial gravity training on orthostatic tolerance following 60-day strict head-down tilt bedrest.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2023
Same author

[Update 2022: interdisciplinary statement on airway management with supraglottic airway devices in pediatric emergency medicine-The laryngeal mask is and remains state of the art : Joint statement of the Institute for Emergency Medicine and Medicine Management (INM), the University Clinic Munich, LMU Munich, Germany, the Working Group for Pediatric Critical Care and Emergency Medicine of the German Interdisciplinary Society for Critical Care and Emergency Medicine (DIVI), the Medical Directors of Emergency Medical Services in Bavaria (ÄLRD), the Scientific Working Group for Pediatric Anesthesia (WAKKA) of the German Society for Anesthesiology and Intensive Care Medicine (DGAI), the Scientific Working Group for Emergency Medicine of the German Society for Anesthesiology and Intensive Care Medicine (DGAI) and the Society of Neonatology and Pediatric Critical Care Medicine (GNPI)].

Die Anaesthesiologie·2023

Area of Science:

  • Immunology
  • Ophthalmology
  • Transplantation Science

Background:

  • Rising demand for corneal grafts necessitates improved matching strategies.
  • Human Leukocyte Antigen (HLA) typing is crucial for preventing immune reactions in corneal transplantation.
  • Non-major histocompatibility complex (non-MHC) antigens, including blood groups and minor antigens, also play a significant role in graft acceptance.

Purpose of the Study:

  • To review current matching strategies for corneal transplantation.
  • To discuss the possibilities and limitations of Human Leukocyte Antigen (HLA) and tissue typing.
  • To explore advanced matching approaches beyond numerical HLA antigen correspondence.

Main Methods:

  • Review of literature on corneal graft matching and immunological principles.

Related Experiment Videos

  • Analysis of different tissue typing strategies, including HLA and non-MHC antigens.
  • Discussion of advanced matching considerations like permissible and taboo mismatches.

    • Main Results:

    • Current matching strategies are evolving beyond basic HLA typing.
    • Non-MHC antigens and specific mismatch classifications are increasingly important.
    • A shift towards functional matching strategies is proposed over purely numerical approaches.

    Conclusions:

    • Effective corneal graft allocation requires differentiated matching strategies.
    • Considering individual waiting times, non-MHC antigens, and specific HLA loci enhances graft utilization.
    • Future strategies should focus on functional matching for improved outcomes in corneal transplantation.