Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Developmental changes in eyeblink conditioning and simple spike activity in the cerebellar cortex.

Daniel A Nicholson1, John H Freeman

  • 1Department of Psychology, University of Iowa, Iowa City, IA 52242, USA.

Developmental Psychobiology
|January 6, 2004
PubMed
Summary

Cerebellar Purkinje cell activity shows age-related learning changes during eyeblink conditioning in infant rats. This suggests developmental plasticity in brainstem-cerebellum circuits influences learning acquisition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Automated device for permitting free movement during simultaneous photometry and electrophysiology in mice.

Nature methods·2026
Same author

Lateral Cerebellar Nucleus Lesions Disrupt Rule-Based Category Learning and Cognitive Flexibility in Rats.

bioRxiv : the preprint server for biology·2026
Same author

Communication between the medial frontal cortex and mediodorsal thalamus is required for timing performance in rats.

Neurobiology of learning and memory·2026
Same author

Stimulus Contingency and Task Context Encoding within the Anterior Cingulate-Amygdala-Cerebellum Associative Learning Network.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025
Same author

Dissociable Roles of the Dorsolateral and Ventromedial Prefrontal Cortex in Human Categorization.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2024
Same author

Regulation by Presynaptic NMDA Receptors of Non-Linear Postsynaptic Summation of the Cortical Input to CA1 Pyramidal Neurons.

Neuroscience·2024

Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Behavioral Neuroscience

Background:

  • Cerebellar neuronal activity demonstrates learning-related plasticity during eyeblink conditioning in adult mammals.
  • Cerebellar feedback maturity to brainstem afferents, like the inferior olive, may impact learning-related changes in developing rats.

Purpose of the Study:

  • To investigate developmental changes in cerebellar plasticity during eyeblink conditioning.
  • To examine the activity of Purkinje cells in infant rats during this learning task.

Main Methods:

  • Recording Purkinje cell simple spike activity in the cerebellar cortical lobule HVI (lobulus simplex) of infant rats.
  • Conducting eyeblink conditioning experiments across different ages.

Main Results:

Related Experiment Videos

  • Eyeblink conditioned response percentage and amplitude increased with age.
  • Developmental increases were observed in the number of Purkinje cells showing stimulus-evoked and learning-related activity changes.
  • The magnitude of these activity changes significantly increased with age.

Conclusions:

  • Cerebellar plasticity and eyeblink conditioning ontogeny are influenced by developmental changes in brainstem-cerebellum circuits.
  • Synaptic interactions within these circuits undergo maturation, supporting the emergence of learning-specific plasticity.