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Updated: Aug 29, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Chromosomal translocation t(18;21)(q23;q22.1) indicates novel susceptibility loci for frontotemporal dementia with
Johannes Prudlo1, Burkhard Alber, Vera M Kalscheuer
1Department of Neurology, University Hospital, Homburg/Saar, Germany. nejpru@uniklinik-saarland.de
Abstract:
A chromosomal translocation t(18;21)(q23;q22) is reported in a patient with frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). We exclude the physical involvement and silencing of the ALS-linked gene for copper/zinc superoxide dismutase (SOD1) on chromosome 21q22.1. The breakpoints are assigned to sequences flanked by the markers ATA1H06, D18S462, D21S1915, and D21S1898. These critical regions may contain susceptibility loci for FTD associated with ALS.
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